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There were 309 women in the phenobarbital group and 301 in the placebo group.A total of 247 women(80 percent)in the phenobarbital group and 235 (78 percent)in the placebo group delivered within 24 hours after infusion of the study drug or administration of the last maintenance dose. Intracranial hemorrhage or early death occurred in 83 of the 344 infants born to the women in the phenobarbital group(24 percent)and in 74 of the 324 born to the women in the placebo group(23 percent;risk ratio for the infants in the phenobarbital group,1.1;95 percent confidence interval,0.8 to 1.4).Among infants born before 34 weeks'gestation in whom ultrasonographic studies were performed,intracranial hemorrhage was diagnosed in 70 of 311 infants in the phenobarbital group(23 percent)and 64 of 279 in the placebo group(23 percent;risk ratio,1.0;95 percent confidence interval,0.8-1.4).Antenatal administration of phenobarbital does not decrease the risk of intracranial hemorrhage or early death in preterm infants. |
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cerebrovascular accident,prevention of
hemorrhage,intracranial,newborn
hemorrhage,periventricular
intracerebral hemorrhage
phenobarbital
premature infant
premature infant,problems in
prevention of neurologic disorders
treatment of neurologic disorder
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